My most frustrating side effect is when I take a targeted therapy. Verzenio is my latest and I am no longer taking it. I took it for 8 months and never felt it worked as reflected in my blood work. Every morning, I do prolonged fasting since I follow the Keto for Cancer lifestyle. When I took Verzenio on an empty stomach in the morning, it caused nausea. This nausea interfered with my daily physical exercise and yoga class. I am now waiting on a new drug Piqray. It comes with the usual list of side effects so I will know soon once I begin taking it. Rash? hyperglycemia? nausea? Stand by....If anyone has taken Piqray and can give me some feedback, it would be greatly appreciated. Piqray was just approved in May 2019. I am positive! Stay Amazed. Linda C.