What Is Kanjinti™ (trastuzumab-anns)?
Reviewed by: HU Medical Review Board | Last reviewed: June 2023 | Last updated: September 2023
Kanjinti™ (trastuzumab-anns) is used to treat certain people with metastatic breast cancer that is positive for the human epidermal growth factor receptor 2 (HER2+). It is used for HER2+ metastatic breast cancer:1-3
- In combination with paclitaxel as a first-line treatment
- Alone in people who have previously been treated with at least one chemotherapy course for metastatic breast cancer
Metastatic breast cancer is cancer that has spread to other parts of the body, such as the bones or liver. Breast cancer tumors are defined as HER2+ or HER2- cancers. HER2 refers to a specific protein that appears on the surface of cancer cells and can lead to faster growth and spread of the cancer. When cancer cells produce too many HER2 molecules, they are called HER2+ tumors.1-3
Kanjinti is also used as adjuvant therapy for certain forms of HER2+ early breast cancer. Adjuvant therapy attempts to keep cancer from coming back after initial treatment, like surgery.1-3
How does Kanjinti work?
Kanjinti is a monoclonal antibody. Antibodies are a normal part of our immune system that act against antigens. These include bacteria, viruses, and other foreign organisms that threaten our health. Monoclonal antibodies used in cancer treatment are created in a lab to attach to specific antigens on the surface of cancer cells.1-3
Certain breast cancer cells have large numbers of HER2 proteins on their cell surfaces. HER2 proteins stimulate tumors to grow especially fast. Kanjinti targets these proteins to block the growth and spread of of HER2+ breast cancers.1-3
Kanjinti only works on tumors with high levels of HER2. Your doctor will test your tumor for HER2 before prescribing this drug.1-3
What are the possible side effects?
The most common side effects of Kanjinti, depending on the specific form of breast cancer being treated, include:3
- Heart problems
- Congestive heart failure
Kanjinti has a boxed warning, the strictest warning from the US Food and Drug Administration (FDA). This is because it may cause severe side effects, including:3
- Heart problems, including congestive heart failure
- Lung damage
- Infusion-related reactions
- Birth defects and death in unborn babies
If you have any new or worsening signs of side effects, contact your doctor right away.
These are not all the possible side effects of Kanjinti. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Kanjinti.
Other things to know
Your doctor will monitor your heart function before and during treatment with Kanjinti.
Before taking Kanjinti, tell your doctor if you:3
- Have any allergies, including medication allergies
- Have or have had heart disease
- Have or have had lung disease, a tumor in your lungs, or difficulty breathing
Kanjinti can harm an unborn baby. If you can become pregnant, you should use birth control during treatment and for some time after the last dose of Kanjinti. Talk to your doctor about your options for birth control while taking Kanjinti. Additionally, if you are breastfeeding or plan to breastfeed, talk with your doctor about this consideration to make sure you have a plan that is safe before starting treatment.3
Before beginning treatment for breast cancer, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.
For more information, read the full prescribing information of Kanjinti.