What is Lynparza® ? (olaparib)

Lynparza is a targeted treatment manufactured by AstraZeneca that is used in people with metastatic breast cancer that is human epidermal growth factor receptor 2 negative (HER2-) and positive or suspected to be positive for a specific BRCA mutation, also known as gBRCA. Lynparza should be given to those who have previously received chemotherapy. For those with breast cancer that is hormone receptor positive (HR+), they should have previously received a hormone therapy, if hormone therapy was determined to be appropriate for the individual.1

What is the active ingredient in Lynparza?

Lynparza contains the active ingredient olaparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes.1

How does Lynparza work?

PARP enzymes are important for cellular functions like DNA repair. DNA is replicated any time a cell divides, and the rapid growth of cancer cells creates more opportunities for DNA damage to occur. Damage to the DNA of cells, including cancer cells, can lead to cell death. Normally, cells have multiple ways of repairing damage that may occur to the DNA. By blocking the PARP repair functionality, Lynparza can limit the cancer cell’s ability to repair its DNA and can lead to the death of cancer cells.2,3

What are some of the possible side effects of Lynparza?

Lynparza may also affect the ability of healthy cells to repair DNA and may cause side effects, some of which may be serious. Serious side effects may include1,2:

  • Myelodysplastic syndrome (MDS), a type of blood cancer that develops from immature blood cells in the bone marrow and may cause symptoms such as low blood cell counts, weakness, and/or bruising easily.
  • Acute myeloid leukemia (AML), a type of blood cancer that develops from myeloid cells, the cells that normally develop into red blood cells, platelets, and white blood cells and may cause symptoms such as low blood cell counts, fatigue, weight loss, and/or fever.
  • Pneumonitis is an inflammation of the air sacs (alveoli) in the lungs, which can lead to death. Symptoms of pneumonitis include difficulty breathing, fever, cough, or wheezing.

The most common side effects experienced by patients taking Lynparza in clinical trials include1,2:

  • Anemia (lowered number of red blood cells)
  • Fatigue
  • Nausea
  • Vomiting
  • Neutropenia and/or leukopenia (lowered number of white blood cells)
  • Respiratory tract infections and/or influenza (flu)
  • Diarrhea
  • Joint or muscle pain
  • Changes in the sense of taste
  • Headache
  • Decreased appetite
  • Indigestion
  • Constipation
  • Inflammation of the mouth

There may be other possible side effects experienced with Lynparza. People taking Lynparza should talk to their doctor about any potential side effect that is bothersome or that persists.

Things to know about Lynparza

Because Lynparza can lower blood cell counts, patients taking Lynparza should have blood tests regularly, including before treatment with Lynparza begins, and throughout treatment.1,2

Before starting treatment with Lynparza, patients should talk to their doctor about all their medications (prescription and over-the-counter), herbal supplements, and vitamins they are taking. Some medications or supplements may interfere with each other and may cause side effects.1,2

Before starting treatment with Lynparza, patients should discuss with their doctor all their medical conditions, especially:

  • Lung or breathing problems
  • Kidney problems
  • If patients are pregnant, planning to become pregnant, or become pregnant
  • If patients are breastfeeding or planning to breastfeed1,2

Lynparza can cause harm to an unborn fetus and should not be used in pregnant women. Women who can become pregnant are advised to use effective contraception while taking Lynparza and for at least six months after stopping treatment with Lynparza. Men who are taking Lynparza and have female partners who can become pregnant should use effective contraception while taking Lynparza and for at least three months after stopping treatment with Lynparza.1,2

It is not known if Lynparza passes through breastmilk. Women should not breastfeed while taking Lynparza and for at least one month after treatment is finished.1,2

Patients taking Lynparza should avoid consuming grapefruit, grapefruit juice, Seville oranges, and Seville orange juice as these products may increase the amount of Lynparza in the blood, which can increase the potential for side effects.1,2

Dosing information

Lynparza is a tablet that is taken by mouth twice daily. It may be taken with or without food.1

Lynparza comes in 100 mg tablets or 150 mg tablets. The recommended dose is 300 mg twice daily. However, in certain cases, the dose may be reduced or stopped due to side effects experienced.1

Patients should take their medication as prescribed by their doctor. Patients should talk to their doctor if they have any questions, or if they have questions regarding their Lynparza regimen.

View References
  1. Lynparza prescribing information. AstraZeneca. Available at https://www.azpicentral.com/lynparza_tb/pi_lynparza_tb.pdf. Accessed 8/22/18.
  2. Lynparza product website. AstraZeneca. Available at https://www.lynparza.com/breast-cancer/what-is-lynparza.html. Accessed 8/22/18.
  3. Clancy, S. (2008) DNA damage & repair: mechanisms for maintaining DNA integrity. Nature Education 1(1):103. Available at https://www.nature.com/scitable/topicpage/dna-damage-repair-mechanisms-for-maintaining-dna-344. Accessed 8/22/18.